The product is based on fibroblast cultures, which help to form collagen, and therefore have a protective effect on aging. However, since the fibroblasts that made the conditioned media are not mine, does my immune system reject the cytokines/proteins and such that they secreted into the conditioned media? Also, how hardly are these cytokines/proteins in a non-controlled environment compared to culture in an incubator or in a -80 freezer? I am wondering if any of you have had experience with fibroblasts and their conditioned media, or anti-aging products and might be able to explain whether or not I am wasting my money?
Thanks!
http://www.skinmedica.com/skin-care-products/rejuvenation/tns-recovery-complex
Key Ingredients
Human Fibroblast Conditioned Media (TNS®) → A physiologically balanced, naturally secreted and stabilized combination of multiple natural messenger proteins
Ingredients
Human Fibroblast Conditioned Media, Isoceteth-20, Ethoxydiglycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Methylparaben, Propylparaben, Isobutylparaben, Butylparaben, Ethylparaben, Fragrance/Parfum, Hydroxycitronellal, Linalool, Coumarin, Alpha-Isomethyl Ionone, Geraniol, Isoeugenol
Fibroblasts are cells that are capable of going though some process and produce collagen. The inactive form of fibroblast is called fibrocytes and Fibroblast plays a huge role in wound healing. I read a scientific article which I attached the link to this comment, It mentioned that when collagen type I and III production is reduced, it is the sign of aged skin. They studies the skins of 18-29 years old and compared it to 80+ years old group. They found that the procollagen which is a marker for college has decreased by 68% in aged skin.
ReplyDeleteOverall I agree that collagen could play a role in making our skin looks less old but I wouldn’t recommend the anti-aging product that you talked about. One of the reasons is the ingredients “human fibroblast conditioned media.” In my opinion I feel that it could trigger immune response since it is foreign to body. My recommendation to you is save your money from this product. Is this product approved by FDA?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1606623/
Like okongo said a fibroblast is a type of cell that synthesizes the extracellular matrix and collagen. It is true that as we age, our skin cells are damaged by chemicals and sunlight resulting in lower amounts of these important natural chemicals being produced, causing sagging and wrinkles.
ReplyDeleteAnd The human fibroblast conditioned is the byproduct of a complex tissue engineering process: Progenitor cells of which are taken from newborn baby foreskins or human fat-adipose-cells.
Therefore, I agree with okongo that it is foreign to our body and it may trigger our immune response.
So, definitely stop using and save your money until further confirmed informations accomplished. And I was just wondering how long have you been using it? and have you had any side effects?
Any sort of product that we use on our skin or anti-aging formula is definitely something that should be under constant scrutiny. It should be most definitely questioned when the advertisers throw in various terms like "scientifically proven" or other "research based" evidence. No matter what kind of product it is, one should always be wary of it. Just like what is being stated in previous comments, it is foreign and could trigger more of an immune response than anything, and could prove to be counterproductive. A lot of products tend to prove to be a hoax despite the background of all the products. When it comes to products, people want to put hope that a certain product can quickly change things, from weight loss products to anti-aging products. But sadly, there is no quick cure to conditions that people consider ailments.
ReplyDeleteI don't think it's a "hoax" because they really don't claim that it can do anything more than the ordinary skin creams advertised on TV. It is fantastically expensive, though, which seems to be taking advantage of people who really need something to help their skin; one bottle is about the price of a visit to a dermatologist, hint hint. It isn't common to get immune responses to proteins applied to the skin, but there are quite a few chemicals in there, so contact dermatitis (Type IV immunopathology) is always a possibility.
ReplyDeleteI also don't think this product is anymore better than the over counter skin product. I did some research on this product and found out that stinging, peeling, flaking, and redness are common but as you keep using it your skin will get used to it. I was wondering if you had these side effects?
ReplyDeleteThey also use a active ingredient called NouriCel-MD in this product, which was actually developed for wound healing to grow fibroblast to repair cell that also make collagen and help with wounds and burns, so they assume that it might help with anti aging and sun damage skin.But I don't think this product will go deep into our dermis to penetrate our skin. And I also found that research on this product was financed by the company that manufactures the TNS Recovery Complex, so the result can be bias too.
http://www.hirshdermatology.com/nouricelmd.htm