This article caught my eye while I was
searching more data for NSAIDs. This study is about the two drugs I talked
about in class today, meloxicam (MXC) and diclofenac (DCF). They used random
patients with osteoarthritis (OA) of hip or knee. There were 300 patients for
this study, 169 treated with MXC and 167 with DCF. Their results showed that both
drugs were well tolerated, although severe adverse events, treatment
withdrawals and clinically significant laboratory abnormalities were more
common with diclofenac than with meloxicam. Thus, meloxicam 7.5 mg is a safe
and effective treatment for OA of the hip and knee, which demonstrates a trend
towards an improved safety profile compared with diclofenac.
The
paper expressed there is limitation with NSAIDs in the treatment of OA due to
relatively high incidence of GI adverse events. They also suggested that
selective inhibition of COX2 over COX1 could prevent this issues which we
talked about it today in class that new research actually saying the opposite
thing.
http://rheumatology.oxfordjournals.org/content/35/suppl_1/39.full.pdf
Interesting article Diyana, I did see that meloxicam was safer than diclofenac however it did not seem to much safer. The GI tract problems were more significant in diclofenac however adverse effects were seen in 59.8 % of subjects on meloxicam and 60.5 % with subjects on diclofenac. Due to how close these percentages are and considering the study was for only 6 months it seems new treatments should be sought out.
ReplyDeleteNSAIDs are only treating the symptoms of OA and knowing this I would expect patients needing to take these drugs longer then just 6 months. I read an article about a new type of treatment that seems to promote osteoblast activation and inhibit osteoclast-mediated bone resorption. The drug is called strontium and might be a new route of research and treatment, however it to has its side-effects.
http://www.ncbi.nlm.nih.gov/pubmed/23117245
Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and fever reducer effects. It is a derivative of oxicam, closely related to piroxicam, and falls in the enolic acid group of NSAIDs.It was developed by Boehringer-Ingelheim. Meloxicam starts to relieve pain 30–60 minutes after administration.
ReplyDeleteInfact, this is not the treatment it is just a pain management while the problem is still in its place and when the drugs are not taken, the problems starts again so a patient of OA must visit Chiropractor North Ryde to get the root cause out.
ReplyDeleteHey what a brilliant post I have come across and believe me I have been searching out for this similar kind of post for past a week and hardly came across this. Thank you very much and will look for more postings from you.
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