I came across a news article on Science Daily that talked about an exciting possible treatment for Rheumatoid Arthritis and other autoimmune diseases and goes along well with our scientific article week for arthritis. Researchers found that infusions of CD8+ Treg cells that were given to mice at the same time as a protein that triggers the arthritis-causing immune reaction, it almost completely inhibited the disease. These Tregs work because they can be recruited to kill off the subset of the harmful T helper cells that are causing the arthritis. In class we talked about how this scenario won't exactly make a good treatment because we don't know when someone will get arthritis and since it is a progressive disease, it can be hard to immediately diagnose. However, this study also shows that even when the CD8+ Treg infusions were administered weeks after the disease was initiated and combined with low doses of methotrexate, they were able to significantly slow the arthritis process. This strategy also works when the scientists injected peptide antigents to expand the rodent' own pool of CD8+ Tregs. They also believe this strategy could be a possible therapeutic approach to other autoimmune disorders.
What do you guys think of this type of treatment and do you think it would be a good idea to move it from testing on rodents to testing it on humans?
Here is the link to the news article: http://www.sciencedaily.com/releases/2013/02/130208124741.htm
I don't think it will be a smart idea to start testing on humans. First of all, it might just be too early. Second of all, as we have been saying in class, humans aren't mice. One of the parts that reminded me of this in the article was when it said how in mice the CD-4 T helper cells have a Qa-1 marker, but in humans, we have HLA-E.
ReplyDeleteI also agree with what you say in which arthritis is a disease in which it won't be diagnosed right away and it can progress. That's one of the reasons why I don't know if this will be a viable treatment. What if by the time that they are diagnosed, there is too much damage already and halting the progression won't do much? I think this leads to the point that people should have regular checkups with their doctor if it is affordable to them.
On the article itself though, I really liked how it was like a lay article but it went in some detail with all the immunology information.
I read the article from Science Daily & found it to be very interesting. Although this seems like it could be a promising treatment, one of my main concerns is what this treatment targets. The article says, "...the strategy described in the new report is aimed "upstream," where the attacks begin with overactive immune fighters, called T follicular helper cells, that mistakenly respond to "self" markers on healthy cells." Instead of focusing on the downstream inflammation and cytokines, they are looking at the CD4 T-follicular helper cells causing the damage. Although this is smart, I am worried that targeting the T follicular helper cells by injecting T regulatory cells will cause unforeseen problems elsewhere in the body. Although T follicular helper cells are overactive and help to cause Rheumatoid Arthritis in the joints, they are still very useful in the body. Can they only eliminate the overactive T follicular helper cells causing the problem, or will this treatment get rid of some T follicular helper cells that we need in our immune system? Should we mess with an immune system that is already out of balance? I think researchers should address these possibilities before moving trials to humans.
ReplyDeleteI agree with both of you in that this is done on mice so we don't know if it would actually work on humans, and that I would also be concerned of what may happen elsewhere in the body when using this type of treatment. However, like people have discussed in class, someone who has arthritis and is in horrible pain and has a poor quality of life, they may be willing to try anything. If this treatment were to allow someone to be pain free I think they would rather live pain free and possibly have other problems or have a shorter life as opposed to having a very poor quality of life.
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