Inflammatory bowel disease is
actually a chronic condition in gastrointestinal track. In IBD, as we disgusted earlier in class, CD can effect
different areas of the digestive track, and involves the whole intestinal wall,
while UC is an ulcerative and inflammatory disease and it’s usually limited to
superficial layers of the colon, such as mucosa and superficial part of the sub
mucosa.
Animals like dogs and cats might also develop IBD some way similar to
human. IBD have the same incidence in males and females, and middle-aged dogs
seem to be more affected. Different breeds of dogs will actually develop
different type of IBD.
Information in dogs with IBD
In dogs, the development of IBD
is a result of a deregulation of mucosal immunity in predisposed animals. On
the other hand the loss of tolerance to antigens is one of the most studied
mechanisms that could justify the development of chronic intestinal
inflammation. Interruption of the mucosal barrier, independently of the primary
cause (bacterial, chemical, etc.), can also lead to further antigen
exposure, allowing the process to become chronic, and is enforced by decreased
apoptosis of lymphocytes, as demonstrated in dogs with IBD.
Also based on this research, IBD in dogs, similar to humans, shows
some relationship with genetic factors and even enteric bacteria can play a
pivotal role in the pathogenesis of these disorders.
An important development in human medicine has shown the different
involvement of lymphocyte subtypes (Th1 and Th2) in IBD, with Th1 being mainly
implicated in CD while Th2 predominate in UC, with subsequent different
cytokine activation.
Here for dogs, things are different, even though it has recently been
hypothesized that different Th cells can be involved in different IBD types, we
can see that there is mixed activation of Th1 and Th2 in IBD, which will cause
different expression of some cytokines.
The signs, symptoms, and
history of dogs and cats with IBD are similar to many, many diseases:
intermittent, chronic vomiting, diarrhea and weight loss in dogs. There are
also some other symptoms such as, flatulence, anorexia, ravenous appetite,
bloody or mucosal stools and abdominal pain. So that’s why we need to do some
examinations, such as Blood tests, urinalysis, specialized blood tests, and
radiographs to determine if the symptoms are those of IBD or some other GI
condition. Intestinal biopsy is the ONLY way to conclusively determine if the
condition in question is IBD. Hypoallergenic diets may be tried to see the
response to treatment.
The causes of IBD in animals aren’t well understood. But similar to
human it seems that genetics, diet, intestinal infection and abnormalities of a
dog's immune system all play a role. The intestine is responsible for
processing large amounts of food and bacterial particles called antigens.
Antigens recognized by a
dog's body, which are called "foreign" can cause an abnormal allergic
(immune-type) response, so the lining of the intestine is invaded with
inflammatory cells and this inflammation will cause the lost of ability to
digest and absorb nutrients.
Common antigens in the intestine include proteins and preservatives from
the food, parasites, viruses or bacteria, and ingested foreign material, of
these antigens can start an abnormal immune response but even when the antigen
is no longer present, the inflammation continues. In most instances, an exact
underlying cause cannot be identified, so that’s why we call this idiopathic
IBD.
What is the
long-term prognosis for dogs with IBD?
IBD can’t be cured, but there are some ways that we can control it. In
all patients with IBD we can use anti-inflammatory medication and also a strict
to be able to manage this disease. Most dogs with IBD do well for many years
while others require alterations in therapy every few months to treat flare-ups
and recurrent symptoms. Unfortunately, a few dogs will fail to respond to
treatment. If the symptoms are severe enough, IBD can progress to intestinal
cancer, so dogs have to be examined several times a year to keep the disease
under control.
this is really interesting, i never though that dogs can get IBD and i think this could be beneficial to compare and contrast between human and dog's IBD and get a better understanding of the disease, because the dog's system is a bit different and may react a bit different to the disease
ReplyDeleteYes, this is interesting and yes dogs can also get IBD and i found this article online which talks about these cats having IBD and they have similar signs, symptoms, and reasoning. And they used these cats in the study of IBD in human beings.
ReplyDelete
ReplyDeleteAlthough therapy has become more tolerable and once daily FDC tables have made it easier to adhere to prescribed treatment, it still requires that patients take their medication regularly to achieve sustained viral suppression. When treatment adherence is inadequate and replication is therefore not suppressed, But dr itua promised and fulfilled his promised to me as he said I will share his work to people that are suffering from Infertility, Herpes,Cervical Cancer,Bone Cancer,Brain Cancer,Prostate Cancer,Leukemia,Brain Tumor,Breast Cancer,Blood Cancer,Kidney Cancer,, Hepatitis A/B, Fibroid, HIV/ Aids, Alzheimer's disease, Arthritis, Copd, Diabetes, Liver/Kidney Inflamotry,Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,
Dementia. Fibromyalgia,Bipolar Disorder, Parkinson's disease, I have read a lot of testimony online from Jesus McKinney,Achima Abelard and Tara Omar on how dr itua heal them with his herbal medicine I contacted him on Email drituaherbalcenter@gmail.com /info@drituaherbalcenter.com. then we talk on whatsapp +2348149277967 he gave me instruction on how to drink it for two weeks then after drinking it for two weeks I went for test then I find out I was cured of HIV, I thank him allot i also send him some money for appreciation, Contact this great herbal doctor if you are a sick person.
My name is hoover, my 18 year old daughter, Tricia was diagnosed of herpes 3 years ago. ever since then,we have been going from one hospital to the other. We tried all sorts of pills but all efforts to get rid of the virus was futile. The blisters kept on reappearing after some months. My daughter was making use of Acyclovir tablets 200mg. 2 tablets every 6hours and fusitin cream 15grams. and H5 POT. Permanganate with water to be applied 2x a day but all still show no result. So I was on the internet some months back, to sought for any other means of saving my only child. just then, i came across a comment on dr imoloa herbal treatment and decided to give it a try. i contacted the him and he prepared some herbs and sent it to me together with guidelines on how to use the herbs through DHL courier service. my daughter used it as directed dr imoloa and in less than 14days, my daughter regained her health.. You should contact Dr imoloa today directly on his email address for any kind of health challenge; lupus disease, mouth ulcer, mouth cancer, fever, hepatitis A.B.C., syphilis, diarrhoea, HIV/AIDS, Huntington's Disease, back acne, Chronic renal failure, addison disease, Chronic Pain, Crohn's Disease, Cystic Fibrosis, Fibromyalgia, Inflammatory Bowel Disease, fungal nail disease, Lyme Disease, Lymphoma, Major Depression, Malignant Melanoma, Mania, Melorheostosis, Meniere's Disease, Mucopolysaccharidosis , Multiple Sclerosis, Muscular Dystrophy, Rheumatoid Arthritis, Alzheimer's Disease, parkison disease, vaginal cancer, epilepsy, Anxiety Disorders, Autoimmune Disease, Back Pain, Back Sprain, Bipolar Disorder, Brain Tumour, Malignant, Bruxism, Bulimia disease, Cervical Disk Disease, Cystic Fibrosis, Hypertension, Diabetes, asthma, Inflammatory autoimmune-mediated arthritis. chronic kidney disease, inflammatory joint disease, impotence, feta alcohol spectrum, Dysthymic Disorder, Eczema, Chronic Fatigue Syndrome, constipation, inflammatory bowel disease. and many more; contact him on email- drimolaherbalmademedicine@gmail.com./ also on whatssap-+2347081986098.
ReplyDelete